Our Blog

Announcing the 2048 Ventures VC Fellows '26

At 2048 Ventures, we are obsessed with meeting and backing talented, visionary, early-stage founders building in Vertical AI, Deep Tech, Health, and Bio. We are the highest conviction, earliest-stage investors specifically focused on NYC and Boston.

2048 Ventures Raises an Oversubscribed $82M Fund III

Fresh $82M in capital for 2048 Ventures to lead pre-seed and seed rounds in Vertical AI, Deep Tech, Healthcare and Biotech startups in NYC and Boston.

Our Thesis on Drug Delivery

We’re interested in platforms that have delivery as their secret sauce, what we believe is the next major unlock in therapeutics.

Our Thesis on Drones

At 2048 Ventures, we are obsessed with the future and invest in early-stage startups that build defensibility through data and technology. Lately, we’ve been thinking about the future of drone technologies.

Our Thesis on Video as a System of Record

At 2048 Ventures, we are obsessed with the future and invest in early-stage startups that build defensibility through data and technology. Lately, we’ve been thinking about the future of data capture and storage.

Our Investment in Nionyx Bio

Nionyx Bio builds AAV-based gene therapies to address some of the most potent kidney genetic diseases.

Introducing 2048 Ventures Pre-Seed Fast Track

Pitch 2048 Ventures through our Pre-Seed Fast Track and we will lead your round with a $250K - $750K check. Get money in the bank within 10 business days of the first meeting.

Our Thesis on Pet Longevity

We see two inevitabilities: preventative, integrated care will define the future of pet healthcare, and longevity will become a central pillar in how owners manage their animals’ health.

Our Thesis on Biobanking

Biobanks are evolving from passive sample storage to active engines for insight generation. We see two complementary opportunities: the infrastructure layer that powers their operations and the intelligence layer that unlocks their value.

Our Thesis on Molecular Biosensors

We see two inevitabilities: the rise of biosensors in clinical trials to enable real-world endpoints, and the shift toward non-invasive, continuous monitoring that decentralizes care and replaces traditional lab tests.

Our Investment in Kascaid

Kascaid is building an interstitial fluid biosensor for immune monitoring starting in clinical trials, where more convenient and frequent sampling can reduce dropout and richer data can enable smaller, faster studies.

Our Thesis on Chronic Care Management

We seek to fund embedded and vertically integrated chronic care management solutions.

Our Investment in Nimbus Health

Nimbus Health is building the future of pulmonology.

Our Investment in Aslan Protects

Rethinking public safety with proactive intelligence.

Our Investment in Rondah AI

Rondah AI is building the agentic workforce powering the future of patient engagement for dental service organizations.

Our Thesis on Cell Therapy Infrastructure

We see two inevitabilities: the continued growth in cell therapy adoption and the increasing automation of manufacturing processes, together setting the stage for major advances in scalability, cost-efficiency, and reproducibility.

Our Thesis on Sensors

We seek to find businesses that use low-cost sensors to capture proprietary and valuable data.

Our Investment in Tetsuwan Scientific

Tetsuwan creates autonomous AI scientists that are capable of performing high sophistication tasks, reacting to data, reasoning, and making decisions.

Our Investment in Psyrin

Psyrin is building the next generation of objective, accessible biomarkers for mental health.

Flock Safety Acquires Aerodome to Bring Drone-as-a-First-Responder to American Cities

The story of our investment in Aerodome blends serendipity with thesis-driven, high conviction investing approach that we practice at 2048 ventures.

Our Thesis on Systems of Record

We seek to invest in businesses that capture and own interesting data, turning it into long-term moats and venture-scale outcomes.

Our Investment in TwoStep Therapeutics

TwoStep Therapeutics has a unique and modular peptide technology that selectively delivers therapeutic agents to solid tumors.

Our Thesis on Digital Bioprocessing

By capturing unique data through existing bioprocess workflows and employing AI to fully reimagine these workflows, we can enhance the robustness and efficiency of biomanufacturing operations.

Our Investment in Century Health

Century Health is accelerating drug development and commercialization by applying AI to clinical data previously untapped by biopharma.

Our Thesis on AI

We believe in two major AI opportunities - the first one is around unique data capture through existing workflows and the second is to use AI to fully reinvent the workflows.

Our Investment in Ripple

Ripple is revolutionizing e-commerce with an AI powered marketing suite for brands.

Our Investment in Neobe

Neobe is developing a synthetic biology platform to engineer bacteria that disrupt the extracellular matrix of solid tumors and enhance immunotherapy success.

2023 Year-in-Review

In 2023 we invested in 17 exceptional startups, and now support 81 companies across 58 geographies.

Our Investment in Enurgen

Enurgen is building the operating platform for large scale solar projects.

Our Investment in Aclid

Aclid is building the security and safety API layer for synthetic biology.

Our Investment in Pageport

Pageport helps businesses of all kinds build personalized videos and websites for each prospect.

Our Investment in Aerodome

Aerodome is building a drone-as-a-first-responder platform for public safety.

Our Investment in Wareclouds

Wareclouds is enabling last-mile logistics using peoples’ homes.

Our Investment in Centro Commerce

Centro is building a single source of truth for inventory.

Our Investment in Persist AI

Persist AI uses automation and AI to create slow-release drug formulations 50% faster than conventional methods.

Our Investment in H2Ok Innovations

H2Ok Innovations is developing a mesh sensor system and software for detecting contamination in industrial liquids.

Congrats to the winners of the Spring 2023 Biotech Pitch Competition!

We’re thrilled to announce the winners, Nephrogen and Cloverleaf Bio

Our Investment in FemTherapeutics

FemTherapeutics is personalizing medicine for women using custom gynecological prosthetics.

Our Investment in Adaptis

Adaptis is an AI-powered modeling platform for improving and optimizing the carbon footprint of existing buildings.

Introducing 2048 Biotech Competition

Introducing 2048 Ventures Biotech Competition. The Biotech Competition gives you an incredible opportunity to kickstart your Biotech venture. The winner of the competition will receive $200K on an uncapped SAFE, and the runner up will get $50K.

2022 Year-in-Review

In 2022 we launched an oversubscribed $65M Fund II. The 50 companies we backed out of our Fund I are now worth nearly $2B.

Our Investment in Stabl

Stabl provides a tailored post-operative recovery plan for patients, moving recovery from clinic to home.

Our Investment in Frate

Frate enables peer-to-peer returns for e-commerce brands.

Our Investment in Carma

Carma is the all-in-one community management platform for Web3 projects.

Joining 2048 Ventures

I’m Daniella and I am thrilled to join 2048 Ventures! With a background in computational neuroscience, I’ll be investing in emerging biotech, healthcare, and artificial intelligence 👩🏼‍🔬🧬🧠🤖

Our Investment in Combo

A simple and powerful video editing platform for creators.

Our Investment in Ettos

Ettos is building an e-commerce platform for beauty and personal care products catered to the next generation of Latin American consumers

Our Investment in Kanary

The internet is filled with our personal information. Simply put, the more we participate in this global digital creative, the more information there is.

Our Investment in Inso Biosciences

The Inso Bio automated genomic DNA processing machine gives back valuable time to scientists while producing high quality, high yield samples for sequencing analysis.

Joining 2048 Ventures

Hi there – I’m Julie, and I’m pleased to announce that I’ve joined the 2048 Ventures team. My background in research, communications, and startup allows me to help early-stage bio companies realize their vision.

Our Investment in ApertureData

Just a decade ago, the internet was filled with text. Today, text is receding in favor of its richer, more visual, fun, and information dense rivals: photo and video.

Our Investment in Wirestock

There are over 20M creators around the world producing commercial grade video and photo assets. Ever been to a website and seen a beautiful photo that brings the text to life? Or seen a TikTok of a beautiful mountain landscape?

Bain Capital Leads soona's $35M Series B

soona is a special company. It is special because of its commitment to use creativity to solve problems. It is special because it is on a mission to empower creatives.

2048 Ventures Raises an Oversubscribed $67M Fund II

We are lucky to be backed by a truly incredible group of world class founders, top family offices, and venture capital firms.

Our Investment in Painworth

Painworth has developed a two-sided platform for the personal injury market, that helps connect claimants directly with insurers.

2021 Year-in-Review

2021 was a strong year for the 2048 Ventures Portfolio. The 50 companies we backed over the last 3 years are now collectively worth more than $1B.

Our investment in Valist

Valist uses the building blocks of Web 3.0 to deliver universal package repositories, code signing, and access control. 

Lux Capital Leads Nomic's $17M Series A

We met Dr. Milad Dagher, the founder of nomic, back in April of 2019, after Milad just finished his PhD at McGill University in Professor David Junker's lab.

Bessemer Ventures Leads Gloss Genius Series A

Our Investment in Groundfloor

Exacerbated by a global pandemic, the way we work, live, and play is profoundly changing.

Underscore VC Leads Lendflow's $10M Series A

Lendflow is the market leader in embedded finance infrastructure for vertical SaaS platforms.

Craft Ventures Leads ConverseNow's $15M Series A

A16Z Leads Vitally Series A

A16Z Leads Vitally Series A

Altos Ventures Leads Airspace Link's $10M Series A

Michael Healander and Danny Bradshaw are on a mission to create the next great American infrastructure. We first met the duo in the summer of 2019 and were incredibly impressed with their vision.

Union Square Ventures Leads soona's $10M Series A

Liz Giorgi and Hayley Anderson are special. Hayley is quiet, creative, brilliant. Liz is passionate, emotional, thoughtful, visionary. Together, with incredible sense of purpose and mission clarity.

Our Investment in Impacked

Impacked facilitates the discovery and fulfillment of primary packs by connecting brands and suppliers...

Our Investment in Walnut

Walnut is on a mission to help patients buy-now-and-pay-later...

Our Investment in Gybe

Water is one of the most precious resources we have...

Our Investment in Tangram Vision

Robotics and automation of all kinds are increasingly part of our lives.

Our Investment in Biobox

We are thrilled to finally be able to share that we led the pre-seed round in the Toronto-based company, BioBox.

Our Investment in Koffie

Today, we are proud to announce that 2048 Ventures has invested in New York-based Koffie...

Firstmark Leads nextmv's $8M Series A

When we first met Carolyn Mooney and Ryan O’Neil back in the fall of 2019, we immediately knew that this was a special duo, and that nextmv was chasing after a huge opportunity.

Our Investment in Eli

It’s no secret that women’s reproductive hormones dictate so much of what goes on in their bodies...

2020 Year in Review

Wow, what a year has 2020 been. The global pandemic changed our lives forever.

Our Investment in Flyp

James and Dani have a bold vision: change how second hand clothing is bought and sold online.

Our Investment in Dathic

We are proud to announce our lead investment in New York City’s Dathic alongside First Row Partners, and strategic angels.

Joining 2048 Ventures

Hi gang, I’m Neha Khera and am thrilled to announce that I’ve joined 2048 Ventures as a Partner.

Our Investment in Ware

With the explosion of e-commerce, the size of newly-built warehouses has more than doubled over the past 20 years.

Congratulations to Zann Ali!

Today we are thrilled to share that Zann Ali has been promoted to Principal at 2048 Ventures.

Our Investment in ConverseNow

When was the last time you called into your nearest Domino’s to place a pizza order, or took your car through the local drive-thru?

Our Investment in Turbodega

Bodegas — small-format grocery and convenience stores — are the heart of Latin American communities.

Our Investment in nextmv

How does Uber manage to match millions of passengers with drivers - all in real-time?

Our Investment in Addapptation

Building applications on top of Salesforce is not easy.

Our Investment in nplex

Our newfound ability to efficiently “read” DNA has powered many of the recent advances we have witnessed in biotechnology.

Our Investment in Humane Genomics

While some viruses certainly make us sick, it is also known that others have played a major role in human evolution

How to Pitch 2048 Ventures Without an Introduction

In 2019, we reviewed 2,200 opportunities of which the majority came to us via a direct email.

2019 Year-in-Review

In 2019 we were lucky to invest in 15 startups. We backed a diverse group of truly exceptional founders.

Our Investment in Airspace Link

2048 Ventures leads a pre-seed investment in Detroit-based Airspace Link.

Our Investment in Lantern

2048 Ventures leads a pre-seed investment in New York-based Lantern.

Our Investment in Vitally

2048 Ventures and Founder Collective co-lead investment in Vitally to help bring analytics to Customer Success.

Our Investment in Ratio.city

2048 Ventures leads $1M seed round in Ratio.city - urban analytics and search platform for growing cities.

Our Investment in soona

2048 Ventures leads $1.2MM seed round in soona - provider of affordable, 24-hour, high quality videos for brands.

VentureFizz Interview with Alex

VentureFizz just did a podcast with Alex Iskold, our co-founder and Managing Partner.

2048 Ventures Raises $27M Fund I

Today, we are excited to share that 2048 Ventures has closed its inaugural Fund I.